HIV structure degradation and HIV cure: Abbottabad
HIV structure degradation and HIV cure:
When HIV first enters the human body or human blood stream the virus start circulates throughout the body. The protective surface of HIV is study with particular protein called gp120 and lip membrane envelop inside the capside that contain a viral RNA and viral enzyme.Gp120 protein on the virus is only able to bind with a cell surface called CD4-receptor.The second receptor protein ccr5 present on the surface of macrophages for the virus enter the cell by endocystosis and HIV cycle begin. From given Diagram virus Receptor attached with Lipid envelops if we can break the structure of Lipid envelops by using a enzyme called lipase virus could not be able to attach the surface of cell because the structure of the virus is degrade. The special type of lipase called pancreatic lipase which is working in 37°C and 7.0 PH can be used in this process
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DNA fingerprinting and CRISPR cas9 system:
Leicester university geneticist Alec Jeffreys develops a technique called DNA fingerprinting in 1985 it allows the DNA sample from different people to be compared look for similarities and differences. It used the solving crime and can confirm if the people are related to each other like paternity testing. There is a section of chromosomes where instead of a gene consisting of a long sequence of bases, they are much shorter sequencing of three to five base that is repeated in many times these repeated sequences called short tandem repeats. If we can know the STR sequence of any person then we can design a gRNA.CRISPR to scan through DNA or find specific STR sequences of another person. If the CRISPR does not find the targeted STR sequence it does not bind to it its means that no fluorescence color appears under UV-light but its scan and find its target and this binding create a fluorescence signal its means that STR can occur in given DNA and both persons are related to each other with respect to any point that is father or son or suspect and victim. The DNA we can check is must be labeled with fluorescence color.
Mutation detection via CRISPRCas9 micro-fluid chip:
Author: Umair Masood
In biology mutation is a change in the nucleotide sequences of the DNA of an organism Mainly there are three types of mutation: point mutation, deletion and insertions. Once the mutation has been defined allele specific oligonucleotide hybridization, amplification, heteroduplex formation method referred to as a diagnostic method some advance technique like CRISPR cas9 system is using for selected mutagenesis. Using microfluid and CRISPR cas9 system we can detect a mutation. Let's say you have a DNA sample with fluorescent labeled from patient and you want to make sure that gene you are interested is in healthy gene. We can design a CRISPR to scan through DNA or find specific gene or mutation. The CRISPR scan the DNA if the CRISPR does not find targeted gene it does not bind to it its means that no fluorescence color appears under UV-light but its scan and find its target and this binding create a fluorescence signal its means that mutation can be occur in gene
Identify a gene that makes protein by using cell free protein synthesis system:
Author: Umair Masood
Living cell could genetically modify to perform a faction such as production of protein. However, these genetically modification often dispute with normal cellular function and result in mutation. Defect can be overcome through removing the bacterial membrane which leave the lysate that is perform both transcription and translation. The cell free-protein synthesis also known as invitro protein synthesis is the production of protein without uses of living cell. Gene is act as instruction to make protein. If we can isolate a gene and then apply a cell free protein synthesis system after synthesis the protein, run on gel-electrophoresis we can identify a gene on the basis of protein. Gel electrophoresis is a laboratory technique used to contrasting proteins according to molecular size and charge.
Other News Abbottabad
Muhammad Sohaib fitness trainer
Muhammad Sohaib is a fitness trainer and fitness model who helped in body transformation of many people.
he said that staying active is one of the best ways to keep our bodies healthy. But did you know it can also improve your overall well-being and quality of life?
It’s a natural mood lifter.
Regular physical activity can relieve stress, anxiety, depression and anger. You know that "feel good sensation" you get after doing something physical? Think of it as a happy pill with no side effects! Most people notice they feel better over time as physical activity becomes a regular part of their lives.
It keeps you physically fit and able.
Without regular activity, your body slowly loses its strength, stamina and ability to function properly. It’s like the old saying: you don’t stop moving from growing old, you grow old from stopping moving. Exercise increases muscle strength, which in turn increases your ability to do other physical activities.
Abbottabad has a humid subtropical climate, with mild to warm temperatures during the spring and autumn months, hot temperatures during June and July, and cool to mild temperatures during the winter. The temperature can rise as high as 38 °C (100 °F) during the mid-summer months and drop below −5 °C (23 °F) during the extreme cold waves. Snowfall occurs occasionally in December and January, though it is sparse, while heavy rainfall occurs during the monsoon season stretching from July to September that frequently cause flooding in lower lying parts of the city.
Other News Pakistan
Government of Sindh announced very big recruitment in Sindh Police Force Special Security Unit.
Number of posts:5000+
Salary packages: 43000 plus
Name of Regions.
For Details visit. https://dailyjobinfo.com/sindh-police-special-security-unit-ssu-jobs-2021/
In the amid of garden something thrown by a gust of wind. Though its the age of satire and the age of complications that ignite certain times on us. Everyone has multiple constrains but I find that this age seems to be obscure. So there is no transparency at all, no cool fervor, no newness and no ingenuity. We are often quashed by nature in different embodiment. We only manipulate glamour and enchantment woefully we are worthless and blank from inside. We are full of impediments. We are confuse that monopolize us in some other way. But many times we boldly overthrew our twofold personalities. It would seems clearly that we are inconsistent. We could not set and could not be fix at all. But what to do my dear ones?
We are inimical to our soul mate and pure relations. Just focus on yourself. Give ample time to yourself for the sake of that you start loving yourself and you entrench your own respect. Do it.
If you try it you'll find a true person which still exists in YOU/YOURSELF but in many forms many embodiment.
Always be TRUE to yourself and be true to your blood relations. Because they are very incentive. Don't harm yourself. Oust negativities from yourself. I know we are innocent. We are loving. We are admirable.
You know we are QUETZAL that chirps in a lovely way even in hard and miserable conditions. Be like QUETZAL that sings like a REBBEC in lap. If we remove detestation and hatred from ourselves we'll find a pure thaddeus (courageous heart). Don't be malice to others.
DON'T ACCUSE OTHERS
DON'T BLAME OTHERS
TRUE TO YOURSELF
We are helms in others life where we are doing jeopardize jobs but we wouldn't have any notion that we're doing deeds wheather it is right or wrong. But what to do? We all are in brown study. May be we are feeling down likwise we are in melancholic mood. But how can we change ourselve with time? We could never have try righteous things. We're bad eggs. We are pretending all the things likewise that we are not to the nines. We all might have mixed feelings about anything everything. We might have been stuck. We always see dark things. We never had try vivid and vibrant things. We are scornful beasts. We are busy likewise we cheat people in any and every relation. But we have to subdue our ego. We have to bring it to the knees. We have to pulverize our bad side. We have to crucify our negativity. Go ahead. Scout yourself. Love respect. Respect yourself.
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Vitaj!Toto je nová a peciálne dedikovaná stránka pre vetkých nadencov elektromobility a fanúikov FonTechu, ktorých bavia témy od elektromobilov, cez iné e-dopravné prostriedky, ekológiu, a po to najnovie z tém okolo dotácií, kde denne sledujeme informácie, i je vetko na Slovensku transparentné. Prihlás sa na odber notifikácií a dostávaj najlepie lánky z Fontechu.