Present, Past and Recent advancements i Pasrūr
Present, Past and Recent advancements in combat against COVID-19
Corona virus is member of subfamily Orthocoronavirinae, family coronaviridae and order Nidovirales. Corona virus usually causes respiratory and gastrointestinal infections. The recent outbreak is due to unique ß-corona virus (COVID-19). The virus genome is single stranded RNA positive sense. Various studies have been carried out to find the origin of this virus, phylogenetic analysis have also been performed and it revealed that this virus is from bat origin. Bats serve as reservoir hosts for this virus. This is virus is 82% similar to human corona virus (SARS-CoV) and 50% to MERS-CoV. Studies have revealed that there was transmission of MERS-CoV from bats to camels. There are various theories regarding current virus pandemic.
Corona viruses are RNA viruses and have crown like appearance when observed under electron microscope. Corona word originated from a Latin word coronum means crown like. Its crown like appearance is due to presence of surface glycoproteins. This virus can be classified in four genera. They are α-coronavirus, ß-coronavirus, Deltacoronavirus and γ-coronavirus. The ß-coronavirus is further divided into five lineages. The phylogenetic studies have revealed that the α-coronavirus and ß-coronavirus are transmitted by bats and rodents. Coronaviridae is a large family and the members of this family causes respiratory, GIT, hepatic and neurological disorders. There are about seven coronaviruses that can infect human beings. There are different coronaviruses here that can infect humans includes HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63, these all are under umbrella of α-coronaviruses. These viruses lead to upper respiratory infections and the disease is self-limiting. The immunocompromised and elder people are more prone to these infections. There are other coronaviruses that can cause illness in humans include SARS-CoV, SARS-CoV-2, and MERS-CoV. These viruses can cause respiratory or other systemic ailments. These morality rates are also variable. These are member of ß-coronaviruses. It was thought that the recent outbreak in Wuhan was due to sea food consumption. It was the major reason for human infection. Later, there were cases that were not linked with this mechanism. It was revealed through various studies that it can be transmitted from one individual to another individual so, the people with symptoms of coronavirus are major source of infection transmission. There are various other respiratory pathogens rhinovirus, the transmission is can occur through respiratory droplets and that can be through coughing and sneezing. Aerosol transmission has also been observed in case of exposure to elevated aerosol concentrations in closed facilities. The transmission, in fact, is primarily to family members, healthcare professionals (doctors, nurses, other hospital staff and health workers), and people with close contact with to infected individual. Pathophysiology of the agent is kind of unique, In Coronaviruses, the genomic structure is positive sense single stranded RNA of approximately 30 kilobytes in length and these are largest known RNA viruses and with a 5′-cap structure and 3′-poly-A tail. Starting from the viral RNA, the synthesis of polyprotein in the host is understood. The transcription occurs through the replication & transcription complex that is structured in double-membrane vesicles and via the synthesis of sub-enomic RNA sequences. The virulence of virus is due to nonstructural and structural proteins the nonstructural proteins are able to block the host immune response that’s why there is rapid damage to host system. The structural proteins are involved in assembly and release mechanisms. The virus is still under study and scientists are working on its different structural domains for better understanding and development of treatment. It has also been observed that the virus initiates excessive immune reaction in host and that is known as cytokine storm. This results in excessive tissue damage. The agonist for this cytokine storm is Interlukin-6 that is responsible for activation of various lymphocytes. It also helps in promotion of various other immune cells like involved in differentiation of B lymphocytes. It also helps in release of various acute phase proteins that are responsible for thermoregulation. There are various histopathological studies that have been conducted to understand the virus pathology. The lungs were examined histologically and there were edema and excessive tissue damage. The lungs were filled proteinaceous exudate. Fibrin like material has also been observed. These implications ultimately lead to difficult breathing and pulmonary arrest. The symptoms for COVID-19 infection are fever, coughing, soreness in throat, nasal congestion, headache, malaise, pain in muscles and generalized illness. The multiple organ failure due to sepsis has also been observed in this infection. To date, there is no treatment for this mysterious infection. There are no specific drugs or vaccines available for its cure. Symptomatic treatment has been performed in all countries and patients are treated with oxygen supply through ventilators. The infection can be differentiated with other viral infections like Adenoviruses, Influenza, Parainfluenza, Human metapneumovirus, Respiratory syncytial virus and common cold caused by Rhino viruses.
WHO (World Health Organization) recommendations
Ø Avoid contact with the infected individuals
Ø Frequent washing of hands after contact with people or environment
Ø Avoid contact with domestic or wild animals
Ø Social distancing is really important
Ø Strict hygienic measures should be adopted to avoid sickness
Ø Avoidance of contact by already diseased people with other infected people or environment
These measures should be adopted to avoid getting infected by this notorious pathogen. The governments are doing their best to combat this pathogen. They should be supported and encouraged. The people should listen to their superiors and governments. These are difficult times and will pass. Life is precious. So, stay home and stay safe.
Other News Pakistan
Finding true love
Love between the worshiper and the Creator feels so satisfying and it fills your heart, especially when you know that Allah loves you. Among the names and attributes of Allah is Al-Wadud, meaning The Most Loving, The Most Affectionate, The Beloved, The Loving-Kindness.
To love Allah is more than simply pronouncing your love of Allah; it is acting upon this love by obeying Him, worshiping Him, liking what He likes, and disliking what He dislikes.
“Indeed, Allah loves those who are constantly repentant and loves those who purify themselves.”(Quran 2:222)
Allah loves the patient, the steadfast, the doers of good, those who act justly, those who purify themselves and repent regularly, those who are righteous/God-fearing, the God-conscious, those who do what their Creator asked them to do and refrain from what He prohibited them from doing.
“So Allah gave them the reward of this world and the good reward of the Hereafter. And Allah loves the doers of good.” (Quran 3:148)
To find God is very easy for a human being. God is present in our heart and soul. It is for man how early he chose a path where he discover true love.
Our Nation Delimma
I never Published an Article but the following heart-wrenching Incident forced me to do so which took place yesterday at Rahim Yar Khan Pakistan, where a father hanged his son because he wouldn't stop crying due to hunger while his wife left him few days back when he failed to provide them food to survive due to the ongoing Coronavirus Pandemic. We said that a father is nothing without his son but what will be the condition of that father when he tied rope around a neck of his his own child knowing that he is going to kill him. I can just feel pain and anguish. Nothing else.. Why? Because we are equally responsible for all this.
How many students are studying in different universities of Pakistan but how many know that many employees working there are on daily wages?
I was member of my university hostel mess management committee for the last two years but just two months back i came to know that some waiters and dish washers are working there on daily wages for the last 10 to 15 years. Some of them have school going kids and living on rent. They are waiting for their monthly salary which is not more than 15,000pkr ($100).
When we the students busy praying for our Vacations they are worried about cut-off from their salaries due to those Vacations.
But unfortunately we'll do nothing neither our leaders will. We as a Nation Failed in this and we didn't have any effective strategies.
What will they do now when no one is there to give them job or provide them something to eat for their survival?
We as a Muslims also failed because we forget advices of our Heroes like Hazrat Umar ibn Al-Khattab said if a dog dies hungry on the banks of the River Euphrates, Umar will be responsible for dereliction of duty. Hence we and our Leaders are Responsible for all this.
"Indian Media Hate provoker- Aim's at Muslim Genocide" written by
"Syed Imran Ali Shah"
Sub continent of South Asia consists of Pakistan, Nepal, Bhutan, Bangladesh, Sri Lanka and India , all of these countries are struggling economies, the GDP growth ratio is also very low than the rest of the world, there several reasons for the slow development growth rate, but one of the biggest reasons is the unrest and political instability and conflicts between Pakistan and India,
India wants to establish it's hegemony in the sub continent, being huge in population, so in order to do so it has been poking it's nose in the internal affairs of it's neighboring counties like, Bangladesh, Sri Lank, Afghanistan and Pakistan,
In Indian Occupied Kashmir the world has witnessed ever worst human rights violation in all regards by India for more than 70 years, even Today the people of Indian Occupied Kashmir are facing ever longest curfew of about more than 250 days,
India has become one of the more insecure countries in the world as BJP Government lead by Narindera Modi who is of the mindset to make India a complete Hindu State, as RSS's fascist approach has core agenda,
The media is considered to be the fourth pillar of a nation state, after Parliament, Administration and Judiciary, Media plays a very vital role in mind making of the masses over the importance national issues, but the Indian media has forgot all the basic rules of Journalism, they have ruined the soul of that how should media report, Media is not supposed to promote the agenda of the government but the Indian media is doing this, some renowned Indian TV anchors are deliberately provoking Muslims genocide through their hate debates, Arnab Goswami, Anjana Om Keshyap, Sudhir Chowdhry are one of those so called media professionals, who misbehave with their panelists during their programs, their Top agenda is to always do propaganda against Pakistan every now and then, Indian Media has prove to be very much irresponsible when there was a tension between India and Pakistan during February 2019, they intentionally created the war hysteria,
Even Today when Covid 19 Pandemic has shaken the whole world, it has spread to more than 198 countries and some hundred thousand people have died so far being victims to this Pandemic,
The Indian Media is again working on its hate promotion agenda against the Muslims of India, their channels are blaming Tableeghi Jamaat for the spread of Covid 19 in, where as the number show that they are less than 1000, while right now the Covid 19 patients in India are more than 12000, Muslims of India are being victimized as they are nit being allowed to do their businesses for earning their daily bread and butter, they are even not being treated in the hospitals,
Indian media is deliberately working on the agenda of few corporate giants who are patronizing Indian Government in order to get their vested financial interests,
Many of the international channels have reported the indian media is spreading the hate that may lead to Muslim genocide, if the same pattern of the biased reporting carried on,
The world should wake up now, if the Indian atrocities are not stopped it may give birth to an endless war, and if this war erupted the whole world will be effected by this, the people of Indian Occupied Kashmir should have been given the right of self determination, as per the resolutions of United Nations,
The Indian Media should stop spreading hatred, they should highlight the basic and fundamental issues of their country, it's pitty that a self proclaimed largest democracy has become a worst autocratic nation Today, 50 % of Indian population openly deficates due to unavailability of Toilets,
World can't afford anymore wars, So Indian media should have to be sensible enough
Other world news
Jennifer Lopez ha tenido 5 anillos de compromiso, pero este será el que JAMÁS olvidará - Glamour México
JLo habla de la sortija que le regaló Ben Affleck cuando eran pareja y una divertida historia detrás de este accesorio.
El impresionante anillo de compromiso que Alex Rodriguez le entregó el pasado mes de septiembre a Jennifer Lopez, cuando le propuso matrimonio en una playa, no es el primero de esas características que ella ha recibido a lo largo de su vida. La diva del Bronx ha estado casada en tres ocasiones y comprometida una más: su relación sentimental con Ben Affleck fue una de las mediáticas de principios del 2000 y, aunque no acabó en boda, sí duró el tiempo suficiente para que el actor le regalara una joya adornada con un diamante central rosa tras pedirle que se casara con él. Ese anillo estaba valorado en más de dos millones de dólares y, aunque resultaba cualquier cosa menos discreto, a ella le encantaba: "Ben me había dado un diamante rosa que causó mucho revuelo... bueno, eso no importa. Y no me malinterpretes, a mí me encantó que me lo diera", ha confesado JLo en una entrevista a Zane Lowe para Apple Music. Lo cierto es que era lo bastante vistoso como para llamar la atención de una verdadera apasionada y entendida de las piedras preciosas como Barbra Streisand. "Conocí a Barbra en una fiesta de los Óscar hace años. En aquella época estaba comprometida con Ben Affleck y resulta que a ella le encantan los diamantes, aunque yo no tenía ni idea", ha desvelado. "Se me acercó porque había oído hablar del anillo y me preguntó si podía verlo y también me estuvo haciendo preguntas al respecto. Lo raro es que después seguimos hablando y me preguntó qué se sentía al ser famosa y cómo lo manejaba", ha añadido.
"Dve nedelje pre Uskrsa ušla sam u sobu mog brata, a ona je gola ležala na krevetu. Tada sam počela da sumnjam..." - Alo!
"Svi u selu znaju da njen brat spava i sa muškarcima i sa ženama“.
"Svi u selu znaju da njen brat spava i sa mukarcima i sa enama."Zatekla sam bratanicu u oevom krevetu, posumnjala sam da se meu njima deava incest, kae sestra V.J. iz Paneva koji je osumnjien da je poetkom aprila primorao erku (17) na polne odnose, to je snimao telefonom, pa slao prijateljima na Fejsbuk i nudio im njene seksualne usluge za 2.000 dinara Da mogu, ubila bih roenog brata zbog onoga to je uradio svojoj erki! Sumnjala sam da se meu njima neto deava i poverila sam se majci, ali mi je ona rekla da ni sluajno ne priam to nikome. Moj brat zasluuje doivotnu robiju, ta je uradio detetu od 17 godina, katastrofa." Ovo kae sestra V. J. (43) iz okoline Paneva, koji je osumnjien da je poetkom aprila primorao erku (17) na polne odnose, to je snimao telefonom, pa slao prijateljima na Fejsbuk i nudio im njene seksualne usluge za 2.000 dinara. Podsetimo, V. J., koji je ranije vie puta hapen, osumnjien je da je erku ubedio da stupe u intimne odnose kako bi joj pomogao u karijeri porno-glumice, ali i da bi se obogatili. Sestra uhapenog kae da je van sebe. - Dve nedelje pre Uskrsa ula sam u sobu mog brata, a bratanica je gola leala na krevetu. Tada sam poela da sumnjam da se u naoj kui deava incest, pa sam rekla majci. Ona je kazala da ne prijavljujem nita i da gledam svoja posla. Strano! - kae ona i dodaje: - Moj brat je monstrum! Sve nas je tukao po kui i mene je maltretirao i prijavljivao me za nasilje, pa sam zbog njega dvaput bila u pritvoru. Sagovornica kae da svi u selu znaju da njen brat spava i sa mukarcima i sa enama. - Ali da to radi i s roenim detetom, to niko nije mogao ni da zamisli - kae.